Author

D. van der Hoeven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

A. A. Gorfe· 1 shared A. K. Gupta· 1 shared A. Naji· 1 shared C. V. Pagba· 1 shared H. Liang· 1 shared J. F. Hancock· 1 shared K.-J. Cho· 1 shared M. J. McCarthy· 1 shared

Activity by Year

2018-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

A. A. Gorfe

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1 paper

Recent·Most cited

Discovery of allosteric non-covalent KRAS inhibitors that bind with sub-micromolar affinity and disrupt effector binding

M. J. McCarthy, C. V. Pagba, P. Prakash, A. Naji, D. van der Hoeven, H. Liang, A. K. Gupta, Y. Zhou, K.-J. Cho, J. F. Hancock, A. A. Gorfe

This study identifies a pyrazolopyrimidine-based allosteric KRAS inhibitor with sub-micromolar affinity that disrupts effector binding and inhibits cancer cell growth.

bioRxiv · Oct 11, 2018Biochemistry