Author

A. A. Gorfe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

H. Liang· 2 shared Y. Zhou· 2 shared A. K. Gupta· 1 shared A. Naji· 1 shared B. Lakshman· 1 shared C. M. Hutchins· 1 shared C. V. Pagba· 1 shared D. V. Nissley· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersBiochemistry

H. Liang

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Author profile →

4 papers

Recent·Most cited

Intrinsically disordered membrane anchors of Rheb, RhoA and DiRas3 small GTPases: Molecular dynamics, membrane organization, and interactions

C. M. Hutchins, A. A. Gorfe

This study uses molecular dynamics simulations to analyze how intrinsically disordered regions of small GTPases interact with membranes, showing that lipid sequence complementarity and electrostatic interactions influence conformational dynamics and lipid sorting.

bioRxiv · Apr 25, 2024Biophysics

Conformational ensemble dependent lipid recognition and segregation by prenylated intrinsically disordered regions in small GTPases

M. K. Araya, A. A. Gorfe

This study shows that conformational plasticity of prenylated intrinsically disordered regions (PIDRs) determines lipid sorting in small GTPases, with sequence outside the polybasic domain modulating this process.

bioRxiv · Aug 11, 2023Biophysics

Membrane curvature sensing of the lipid-anchored K-Ras small GTPases

H. Liang, H. Mu, F. Jean-Francois, B. Lakshman, S. Sarkar-Banerjee, Y. Zhuang, Y. Zeng, W. Gao, D. V. Nissley, A. A. Gorfe, W. Zhao, Y. Zhou

This study shows that K-Ras and H-Ras isoforms respond differently to plasma membrane curvature, with K-Ras favoring less curved membranes and H-Ras favoring more curved membranes, mediated by phospholipid sorting.

bioRxiv · Dec 10, 2018 · PreprintBiochemistry

Discovery of allosteric non-covalent KRAS inhibitors that bind with sub-micromolar affinity and disrupt effector binding

M. J. McCarthy, C. V. Pagba, P. Prakash, A. Naji, D. van der Hoeven, H. Liang, A. K. Gupta, Y. Zhou, K.-J. Cho, J. F. Hancock, A. A. Gorfe

This study identifies a pyrazolopyrimidine-based allosteric KRAS inhibitor with sub-micromolar affinity that disrupts effector binding and inhibits cancer cell growth.

bioRxiv · Oct 11, 2018Biochemistry