A. K. Gupta

Synergistic Hypoxia and Apoptosis Conditioning Unleashes Superior Mesenchymal Stem Cells Efficacy in Acute Graft-versus-Host-Disease

This study shows that hypoxia and apoptosis conditioning of WJ-MSCs enhances their immune regulatory capacity in aGVHD by promoting Treg differentiation and M2 macrophage polarization.

A Prodrug Strategy to Reposition Atovaquone as a Long-Acting Injectable for Malaria Chemoprotection

This paper develops three prodrug formulations of atovaquone for long-acting injectable malaria chemoprotection, showing two maintain therapeutic plasma levels for over 70 and 30 days in monkeys.

The mitochondrial thiolase ACAT1 regulates monocyte/macrophage type I interferon via epigenetic control.

This study shows ACAT1 regulates type I interferon via epigenetic control by linking fatty acid metabolism to histone acetylation in macrophages.

Discovery of CMX990: A Potent SARS-CoV-2 3CL Protease Inhibitor Bearing a Novel Covalent Warhead

This paper introduces CMX990, a potent SARS-CoV-2 3CL protease inhibitor with improved potency and clearance compared to nirmatrelvir, advancing to Phase 1 clinical trials.

Transcription elongation defects link oncogenic splicing factor mutations to targetable alterations in chromatin landscape

This paper shows that mutations in SF3B1 and U2AF1 cause transcription elongation defects leading to chromatin changes and identifies targeting the Sin3/HDAC complex as a potential therapy.

Rationally designed inhibitors of the Musashi protein-RNA interaction by hotspot mimicry

This paper designs inhibitors for Musashi proteins MSI1 and MSI2 by mimicking hotspot pharmacophores from protein-RNA complexes, showing specificity and activity in multiple assays.

Targeted protein S-nitrosylation of ACE2 as potential treatment to prevent spread of SARS-CoV-2 infection

This paper develops aminoadamantane nitrate compounds that inhibit SARS-CoV-2 infection by S-nitrosylating ACE2 and blocking viral entry, showing efficacy in vitro and in a Syrian hamster model.

Oral drug repositioning candidates and synergistic remdesivir combinations for the prophylaxis and treatment of COVID-19

The paper identifies 66 compounds that inhibit SARS-CoV-2 replication and 24 that synergize with remdesivir, suggesting potential oral drug repositioning candidates for COVID-19.

Integrative genome-wide analysis reveals EIF3A as a key downstream regulator of translational repressor protein Musashi 2 (MSI2)

The paper identifies EIF3A as a direct target of MSI2 and shows that MSI2 represses EIF3A translation, which amplifies its effects on the proteome.

EVALUATION OF ANTI-BACTERIAL AND ANTHELMINTIC ACTIVITIES OF BARK OF PLANT CASSIA FISTULA Linn.

This study evaluates the anti-bacterial and anthelmintic activities of Cassia fistula bark extracts, finding methanolic extract most effective against gram +ve bacteria and anthelmintic activity comparable to Albendazole.

Synthesis, SAR and Docking Studies of Substituted Aryl phenylthiazolyl phenylcarboxamide as potential PTP-1B Inhibitors

The paper synthesizes and evaluates substituted aryl phenylthiazolyl phenylcarboxamides as PTP-1B inhibitors, identifying compound 38 as a potent inhibitor with in vivo metabolic benefits.

Integrated ligand and structure-based investigation of structural requirements for silent information regulator activation

The paper develops 2D and 3D QSAR models to identify structural requirements for SIRT1 activation, showing significant statistical validation and potential for drug discovery.

Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Anti-oxidant and Anti-hyperglycemic Activity

This study synthesizes and evaluates oxopropanylindole hydrazone derivatives for antioxidant and anti-dyslipidemic activity, identifying 6c as the most effective compound.

Nitric oxide is important for sensing and survival under hypoxia in Arabidopsis

This study shows that nitric oxide modulates gene expression and metabolite levels in Arabidopsis under hypoxia, enhancing survival through fermentation, TCA cycle, and antioxidant metabolism.

Discovery of allosteric non-covalent KRAS inhibitors that bind with sub-micromolar affinity and disrupt effector binding

This study identifies a pyrazolopyrimidine-based allosteric KRAS inhibitor with sub-micromolar affinity that disrupts effector binding and inhibits cancer cell growth.