P. Prakash

Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies

The paper develops a mouse model of aldosterone-producing adenoma to test thermal ablation therapies, showing reduced aldosterone production after treatment.

Assessment of thermochromic phantoms for characterizing microwave ablation devices

This study compares microwave ablation zones in thermochromic gel phantoms and ex vivo bovine liver, finding discrepancies in ablation size and shape under certain conditions.

Three Prime Repair Exonuclease 1 preferentially degrades the integration-incompetent HIV-1 DNA through favorable kinetics, thermodynamic, structural and conformational properties.

This study identifies how TREX1 preferentially degrades unprocessed HIV-1 DNA over 3-processed DNA through kinetic, thermodynamic, and structural differences.

Emergence of synchronised growth oscillations in filamentous fungi

This study observes synchronized growth oscillations in Serendipita indica fungi during sporulation using a microfluidic setup and links it to cell-cell communication.

Anti-Diffusion in an Algae-Bacteria Microcosm: Photosynthesis, Chemotaxis, and Expulsion

The paper studies a microcosm of algae and bacteria, showing that bacterial chemotaxis to oxygen causes algae expulsion from illuminated regions.

Erythrocyte signalling is critical for Plasmodium falciparum invasion

This study shows that Plasmodium falciparum merozoite invasion depends on host cAMP-Ca2+ signalling, with RH5-Basigin interaction triggering cAMP rise and Ca2+ influx.

Reward quantity discrimination in an associative learning task in wild zebrafish (Danio rerio)

This study tests reward quantity discrimination in wild zebrafish using an operant conditioning task and finds some fish can discriminate between stimuli associated with different rewards.

HIV-1 preintegration complex preferentially integrates the viral DNA into nucleosomes containing trimethylated histone 3-lysine 36 modification

This study identifies that HIV-1 preintegration complex preferentially integrates viral DNA into nucleosomes with H3K36me3 modification and linker DNA.

Molecular insights into the inhibition of glutamate dehydrogenase (GDH) by the dicarboxylic acid metabolites

This study investigates how dicarboxylic acid metabolites inhibit Aspergillus terreus GDH by analyzing crystal structures and binding interactions.

One Scaffold - Different Organelles Sensors: pH-Activable Fluorescent Probes for Targeting Live Primary Microglial Cell Organelles

The paper designs pH-activable fluorescent probes with a common scaffold for targeting different organelles in live primary microglial cells, showing differential fluorescence and pKa based on functional group changes.

Long-range coupled motions underlie ligand recognition by a chemokine receptor

This study investigates how Site-I interactions in CXCR1 contribute to ligand recognition by CXCL8 through structural plasticity, using NMR and MD simulations.

Discovery of allosteric non-covalent KRAS inhibitors that bind with sub-micromolar affinity and disrupt effector binding

This study identifies a pyrazolopyrimidine-based allosteric KRAS inhibitor with sub-micromolar affinity that disrupts effector binding and inhibits cancer cell growth.

A "Tug of War" maintains a dynamic protein-membrane complex as shown in all-atom simulations of C-Raf RBD-CRD bound to K-Ras4B at an anionic membrane

The paper uses all-atom simulations to show that a dynamic competition between C-Raf domains and K-Ras4B-membrane interactions maintains a protein-membrane complex for efficient signaling.