A. Naji

Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset

The paper analyzes immune cell changes in human pancreas-draining lymphatic tissues before and after T1D onset, identifying proinflammatory patterns and genetic risk correlations.

MTMR regulates KRAS function by controlling plasma membrane levels of phospholipids

The paper identifies MTMR proteins as regulators of KRAS function by controlling plasma membrane phospholipid levels, specifically PI4P and PtdSer.

A low-cost protocol for reconditioning of deep-brain neural microelectrodes with material failure for electrophysiology recording

This paper presents a low-cost protocol to recondition neural microelectrodes with material failure, demonstrating its effectiveness through experimental results on tungsten electrodes.

DEC1 is an adult clock regulator that links circadian rhythms to functional β-cell maturation

This study shows DEC1 regulates circadian rhythms in β-cells, linking them to metabolic maturation and glucose responsiveness.

Human Vascularized Bile Duct-on-a Chip: A multi-cellular micro-physiological system for studying Primary Sclerosing Cholangitis

This paper develops a vascularized bile duct-on-a-chip model to study PSC, showing PSC cholangiocytes exhibit increased inflammation under IL-17A stimulation.

Kiwa is a bacterial membrane-embedded defence supercomplex activated by phage-induced membrane changes

The paper characterizes the Kiwa defence system as a bacterial membrane supercomplex that detects phage-induced membrane changes and inhibits phage replication.

Injury and a program of fetal wound healing in the fetal and neonatal extrahepatic bile duct

This study investigates the fetal response to injury in extrahepatic bile ducts (EHBDs) and identifies a fetal wound healing program characterized by high molecular weight HA, which may lead to obstruction in biliary atresia.

mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant

This study evaluates the neutralizing activity of mRNA vaccines against the SARS-CoV-2 Omicron variant, showing reduced efficacy after the second dose but improved responses following a third dose.

Efemp1 modulates elastic fiber formation and mechanics of the extrahepatic bile duct

This study shows EFEMP1 is crucial for elastic fiber formation and mechanical properties of the extrahepatic bile duct, with reduced EFEMP1 leading to increased compliance and potential role in biliary atresia.

Alpha cell dysfunction in early type 1 diabetes

The paper identifies early alpha cell dysfunction in individuals with GADA+ status, preceding beta cell loss in T1D, and links it to metabolic pathway abnormalities.

The identity of human tissue-emigrant CD8+ T cells

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

Mapping the lineage relationship between CXCR5+ and CXCR5- CD4+ T cells in HIV infected human lymph nodes

The paper identifies a CXCR5-negative CD4+ T cell subset in HIV-infected lymph nodes that shares lineage and functional traits with CXCR5+ T follicular helper cells.

Discovery of allosteric non-covalent KRAS inhibitors that bind with sub-micromolar affinity and disrupt effector binding

This study identifies a pyrazolopyrimidine-based allosteric KRAS inhibitor with sub-micromolar affinity that disrupts effector binding and inhibits cancer cell growth.