C. Gatsogiannis

The paper presents the structure of the RhsA effector and its cognate VgrG1 spike protein from Pseudomonas protegens, revealing their assembly and potential mechanism of action via the T6SS.

This study shows Pdr5, an ABC transporter, functions as a proton/drug co-transporter, generating a proton motive force during drug efflux, suggesting a more complex mechanism of multidrug resistance.

This study reports cryoEM structures of two Latrotoxins (LaTXs) and proposes a cyclic oligomerization mechanism, revealing structural insights into their molecular action.

TranSPHIRE automates cryo-EM data processing during acquisition, using a feedback loop to improve particle picking and produce high-resolution 3D reconstructions.

The paper introduces crYOLO, a deep learning-based particle picker for cryo-EM that achieves high accuracy and speed, enabling automated data pre-processing.

The paper reports the cryo-EM structure of zebrafish TRPC4 in its closed, unliganded state, revealing key structural features and insights into its function and pharmacology.