Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D beta-lactamases.
Q. Zhou, H. Bell, P. Catalan, P. Baumann, R. Evans, J. Yang, Z. Zhang, D. Zappala, Y. Zhang, G. M. Blackburn, Y. He, Y. Jin
The paper identifies chloride as an allosteric activator and inhibitor of Class-D beta-lactamases, revealing its dual role in enzyme kinetics and suggesting new antibiotic strategies.
bioRxiv · Dec 20, 2022 · PreprintBiochemistry