R. Evans

The Pvc15 D2-Pnf SP Interaction Mediates AAA ATPase Activity, Payload Stability, and Translocation into the PVC Tube Lumen.

This study identifies the role of Pvc15 D2 domain in mediating ATPase activity, payload stability, and translocation into the PVC tube lumen through interactions with the Pnf SP.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

A hybrid and poly-polish workflow for the complete and accurate assembly of phage genomes: a case study of ten przondoviruses

This paper introduces HYPPA, a hybrid assembly workflow for phage genomes, demonstrating its ability to accurately assemble and correct phage genomes without laborious validation.

Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D beta-lactamases.

The paper identifies chloride as an allosteric activator and inhibitor of Class-D beta-lactamases, revealing its dual role in enzyme kinetics and suggesting new antibiotic strategies.

A Synthetic ERRα Agonist Induces an Acute AerobicExercise Response and Enhances Exercise Capacity

A synthetic ERRα agonist activates an acute aerobic exercise genetic program in skeletal muscle, enhancing exercise capacity and mitochondrial function in mice.

The autophagy initiating kinase ULK1 is required for pancreatic cancer cell growth and survival

This study shows ULK1 is essential for pancreatic cancer cell growth and survival, and ULK1 inhibitors can enhance immunotherapy by increasing MHC Class I expression.

Daily running enhances molecular and physiological circadian rhythms in skeletal muscle

This study shows that daily running in mice changes their muscle circadian rhythms and improves exercise performance depending on the time of day.

A Stu2-mediated intrinsic tension-sensing pathway promotes chromosome biorientation in vivo

This study identifies a Stu2-mediated tension-sensing pathway that works with Aurora B to correct kinetochore attachments in vivo.

Mycophenolate mofetil increases susceptibility toopportunistic fungal infection independent of lymphocytes

This study shows that mycophenolate mofetil increases susceptibility to fungal infection by affecting macrophages, not lymphocytes.

A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus

This study shows that RNA viruses evolve high mutation rates as a byproduct of selection for faster replication, not because of adaptive advantages.