Author

H. Bell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:metabolomics· 3 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. A. Lyssiotis· 3 shared Y. M. Shah· 3 shared N. K. Das· 2 shared R. Banerjee· 2 shared R. Kumar· 2 shared R. Singhal· 2 shared S. A. Kerk· 2 shared A. Andren· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCancer Biology

C. A. Lyssiotis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sulfide oxidation promotes hypoxic angiogenesis and neovascularization

R. Kumar, V. Vitvitsky, P. Seth, H. L. Hiraki, H. Bell, A. Andren, R. Singhal, B. Baker, C. A. Lyssiotis, Y. M. Shah, R. Banerjee

This study shows that sulfide oxidation via SQOR promotes hypoxic angiogenesis and neovascularization by reprogramming metabolic pathways in endothelial cells.

bioRxiv · Mar 14, 2023Biochemistry

Discovery and molecular basis of chloride as an allosteric activator and catalytic inhibitor for Class-D beta-lactamases.

Q. Zhou, H. Bell, P. Catalan, P. Baumann, R. Evans, J. Yang, Z. Zhang, D. Zappala, Y. Zhang, G. M. Blackburn, Y. He, Y. Jin

The paper identifies chloride as an allosteric activator and inhibitor of Class-D beta-lactamases, revealing its dual role in enzyme kinetics and suggesting new antibiotic strategies.

bioRxiv · Dec 20, 2022 · PreprintBiochemistry

Microenvironmental Ammonia Enhances T cell Exhaustion in Colorectal Cancer

Y. M. Shah, H. Bell, A. K. Huber, R. Singhal, R. J. Rebernick, R. Kumar, N. K. Das, S. A. Kerk, P. Sajjakulnukit, S. Solanki, J. G. James, D. Kim, L. Zhang, M. O. El-derany, T. L. Frankel, , M. Green

This study shows that ammonia accumulation in the colorectal cancer microenvironment promotes T cell exhaustion and treatment resistance, and that reducing ammonia improves immunotherapy efficacy.

bioRxiv · May 25, 2022Cancer Biology

Microbiota metabolic exchange is critical for colorectal cancer redox homeostasis and growth

H. Bell, J. Goyert, S. A. Kerk, N. K. Das, C. A. Lyssiotis, Y. M. Shah

This study identifies reuterin as a microbial metabolite that suppresses colorectal cancer growth by altering redox balance and inducing cell death.

bioRxiv · Dec 2, 2020 · PreprintCancer Biology