Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family
P. J. Stogios, E. Bordeleau, Z. Xu, T. Skarina, E. Evdokimova, S. Chou, D.-T. Luke, A. D'Souza, S. Patel, G. Dantas, G. Wright, A. Savchenko
The paper analyzes Antibiotic_NAT family enzymes to understand resistance diversification, finding environmental variants confer broad-spectrum resistance and likely ancestral relationships to clinical genes.
bioRxiv · Sep 10, 2021Microbiology