Characterization of a Novel Transmembrane Activating STING Agonist using Genetically Humanized Mice
Nobuyo Mizuno, Jinu Abraham, Kevin Jimenez-Perez, Ian Rose, Laura Springgay, Dylan T. Boehm, Takeshi Ando, Daniel N. Streblow, Janine M. Ward, Shannon M. Miller, Uddav Pandey, Ahmad Junaid, David Joyner, Roshell Muir, Elias K. Haddad, , Victor R. DeFilippis
This study develops a novel transmembrane STING agonist and validates its efficacy in genetically humanized mice, showing enhanced immune and antitumor responses.
Cell Reports · Jun 1, 2026Peer-reviewedImmunology