Adenosine deaminase co-immunization reverses age-associated immunosenescence by restoring germinal center T follicular helper cell function
Emily Nicole Bitsko, David Joyner, Jeffrey R. Maslanka, Kyra Woloszczuk, Arden O. Edgerton, Matthew R. Bell, Christian Sell, Mohamad‐Gabriel Alameh, Joris Beld, Elias K. Haddad, Michael C. Abt, Michele A. Kutzler
This study shows that co-immunizing with adenosine deaminase and a DNA vaccine improves T follicular helper cell function and antibody quality in aged mice, enhancing protection against C. difficile infection.
bioRxiv · Jun 9, 2026 · PreprintImmunology