Daniel N. Streblow

This paper shows that HCMV's UL22A protein is essential for reactivation from latency in CD34+ hematopoietic progenitor cells, with tyrosine residues critical for this process, but RANTES neutralization does not fully restore reactivation.

This study develops a novel transmembrane STING agonist and validates its efficacy in genetically humanized mice, showing enhanced immune and antitumor responses.

This study infects rhesus macaques with a recent ONNV clinical isolate, demonstrating viremia, immune activation, and clinical disease features similar to human infection.

This study evaluates a Zika virus-like particle (VLP) vaccine in rhesus macaques, showing it reduces early pregnancy loss caused by a highly pathogenic ZIKV strain.

This study identifies UL78 as a nuclear-localized GPCR essential for HCMV reactivation from latency in CD34+ HPCs, showing its Gi coupling and interactome involvement in nuclear processes.

This study investigates how obesity affects the long-term effects of SARS-CoV-2 infection in nonhuman primates, finding persistent changes in multiple parameters in most animals.

This study identifies a first-in-class inhibitor of alphavirus nsP2 helicase activity, showing broad antiviral activity and in vivo efficacy against chikungunya virus.

This paper identifies and optimizes oxaspiropiperidine inhibitors targeting nsP2hel, showing nanomolar antiviral activity against multiple alphaviruses.

This study shows that a dominant-negative mutant of the viral chemokine RCK3 prevents CMV-induced neurodevelopmental disorders in a rat model.

This study identifies and characterizes Rhesus CMV-encoded Fcγ-binding glycoproteins, showing they delay antibody-mediated immune control during primary infection.

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.