In Vivo Massively Parallel Reporter Assay Reveals Sequence Determinants of mRNA Localization in Astrocytes
Sarah K. Koester, Kristina Sakers, Gareth M. Rurak, Stephen P. Plassmeyer, Kelli McFarland White, Sebastian Alves Ferreira Dias, Peter Baird, D.J. Kornbluth, Joseph D. Dougherty
The paper develops an in vivo MPRA method to identify sequence determinants of mRNA localization in astrocytes and finds diverse regulatory mechanisms are used.
bioRxiv · Apr 30, 2026 · PreprintNeuroscience