Simona Sarafinovska

SMURF improves spatial transcriptomic analysis by accurately assigning mRNAs to cells and revealing gene-expression zonation in tissues.

This paper develops inducible Calling Cards in mice to control transposon insertion timing in vivo, showing varying efficacy and developmental impacts based on the transcription factor used.

The paper uses single-nucleus RNA-sequencing to link molecular variation in hypothalamic neurons to social motivation behavior in mice, identifying actionable targets for social deficit disorders.

This study investigates how chromosomal and gonadal sex influence social motivation in mice, finding that gonadal sex primarily affects behavior while chromosomal sex interacts with genetic mutations to alter social behavior.

This study examines the role of MYT1L in neuronal development by analyzing gene expression in wild-type and MYT1L-deficient mice, finding disruptions in excitatory neuron proportions and gene expression.

The paper develops a method to assess the functional effects of non-coding elements in specific cell types in vivo using a Cre-dependent MPRA approach.

Calling Cards records protein-DNA interactions over time using transposons, enabling analysis of historical molecular states through sequencing.

This study examines the effects of in utero and postnatal oxycodone exposure on mouse behavior and development, finding sex-dependent weight changes, altered vocalizations, and sensorimotor delays.