Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation
Simona Sarafinovska, Sarah K. Koester, L.Z. Fang, J.W. Thorpe, Sneha M. Chaturvedi, Jeong-Seon Ji, E.F. Jones, Din Selmanovic, D.J. Kornbluth, M.R. Barrett, Gareth M. Rurak, Susan E. Maloney, Meaghan C. Creed, Robi David Mitra, Joseph D. Dougherty
The paper uses single-nucleus RNA-sequencing to link molecular variation in hypothalamic neurons to social motivation behavior in mice, identifying actionable targets for social deficit disorders.
bioRxiv · Mar 10, 2025 · PreprintGenetics