Author

Sarah K. Koester

Washington University in St. LouisORCID 0000-0003-4626-504XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Assay:multiome· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

D.J. Kornbluth· 2 shared Gareth M. RurakiD· 2 shared Joseph D. DoughertyiD· 2 shared Din SelmanoviciD· 1 shared E.F. Jones· 1 shared J.W. Thorpe· 1 shared Jeong-Seon JiiD· 1 shared Kelli McFarland WhiteiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersNeuroscience

D.J. Kornbluth

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintApr 30, 2026

In Vivo Massively Parallel Reporter Assay Reveals Sequence Determinants of mRNA Localization in Astrocytes

Sarah K. Koester, Kristina Sakers, Gareth M. Rurak…·Joseph D. Dougherty

The paper develops an in vivo MPRA method to identify sequence determinants of mRNA localization in astrocytes and finds diverse regulatory mechanisms are used.

DOI 10.64898/2026.04.27.721172

mousemultiome

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GeneticsbioRxivPreprintMar 10, 2025

Single-Cell Resolution of Individual Variation in Hypothalamic Neurons Allows Targeted Manipulation Affecting Social Motivation

Simona Sarafinovska, Sarah K. Koester, L.Z. Fang…·Joseph D. Dougherty

The paper uses single-nucleus RNA-sequencing to link molecular variation in hypothalamic neurons to social motivation behavior in mice, identifying actionable targets for social deficit disorders.

3 citations

mousescRNA-seq

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