Gareth M. Rurak

The paper develops an in vivo MPRA method to identify sequence determinants of mRNA localization in astrocytes and finds diverse regulatory mechanisms are used.

This study shows that norepinephrine modulates synapses via astrocytic adrenergic receptors and Ca2+ dynamics, independent of neuronal receptors.

The paper uses single-nucleus RNA-sequencing to link molecular variation in hypothalamic neurons to social motivation behavior in mice, identifying actionable targets for social deficit disorders.

This study identifies Hmgb1 in astrocytes as critical for postnatal astrocyte morphogenesis and cerebrovascular maturation, affecting endothelial ultrastructure and neurovascular coupling in adult mice.

The paper identifies two distinct astroglial phenotypes across mouse cortical development and reveals significant sex differences in developmental gene expression patterns.