SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulation
Doyeong Ku, Yewon Yang, Youngran Park, Daesong Jang, Namseok Lee, Yong-Ki Lee, Keonyong Lee, Jae‐Seon Lee, Yeon Bi Han, Soojin Jang, Se Rim Choi, You‐Jung Ha, Yong Seok Choi, Woo‐Jin Jeong, Yun Jong Lee, , Yoosik Kim
This study identifies SLIRP as a key amplifier of antiviral signaling in autoimmune diseases through positive feedback regulation of mt-dsRNA.
bioRxiv · Mar 28, 2024 · PreprintMolecular Biology