Yoosik Kim

The paper investigates how intron lariats, especially those with transposable elements, trigger immune responses in cancer cells and shows that RNA editing and DBR1 depletion can be used to enhance anti-tumor effects.

This paper develops a computational framework using dimensionality reduction of genome-scale metabolic models to identify host metabolic vulnerabilities for antiviral targets, validated across multiple coronaviruses.

The paper identifies cellular dsRNA-binding proteins (dsRBPs) using anti-dsRNA immunoprecipitation and mass spectrometry, revealing their role in regulating the interferon response and antiviral defense against HCoV-OC43.

This study identifies SLIRP as a key amplifier of antiviral signaling in autoimmune diseases through positive feedback regulation of mt-dsRNA.

The paper identifies alternative polyadenylation as a key mechanism by which inverted Alu repeats regulate gene expression and contribute to disease.

This study identifies mitochondrial double-stranded RNAs (mt-dsRNAs) as drivers of type I interferon responses and inflammatory phenotypes in Sjogrens syndrome.

The paper identifies dsRNA-binding proteins that mediate decitabine's effects by stabilizing ERV RNAs, showing low Stau1 and TINCR expression correlates with poor treatment outcomes in AML patients.

This study identifies mitochondrial dsRNAs as activators of PKR and TLR3, contributing to chondrocyte degeneration in osteoarthritis.