Yong-Ki Lee

This paper develops a computational framework using dimensionality reduction of genome-scale metabolic models to identify host metabolic vulnerabilities for antiviral targets, validated across multiple coronaviruses.

The paper identifies cellular dsRNA-binding proteins (dsRBPs) using anti-dsRNA immunoprecipitation and mass spectrometry, revealing their role in regulating the interferon response and antiviral defense against HCoV-OC43.

This study identifies SLIRP as a key amplifier of antiviral signaling in autoimmune diseases through positive feedback regulation of mt-dsRNA.

The paper identifies dsRNA-binding proteins that mediate decitabine's effects by stabilizing ERV RNAs, showing low Stau1 and TINCR expression correlates with poor treatment outcomes in AML patients.