The paper identifies cellular dsRNA-binding proteins (dsRBPs) using anti-dsRNA immunoprecipitation and mass spectrometry, revealing their role in regulating the interferon response and antiviral defense against HCoV-OC43.

bioRxiv · Jun 14, 2024 · PreprintMolecular Biology

SLIRP promotes autoimmune diseases by amplifying antiviral signaling via positive feedback regulation

Doyeong Ku, Yewon Yang, Youngran Park, Daesong Jang, Namseok Lee, Yong-Ki Lee, Keonyong Lee, Jae‐Seon Lee, Yeon Bi Han, Soojin Jang, Se Rim Choi, You‐Jung Ha, Yong Seok Choi, Woo‐Jin Jeong, Yun Jong Lee, , Yoosik Kim

This study identifies SLIRP as a key amplifier of antiviral signaling in autoimmune diseases through positive feedback regulation of mt-dsRNA.

bioRxiv · Mar 28, 2024 · PreprintMolecular Biology

Mitochondrial double-stranded RNAs as a pivotal mediator in the pathogenesis of Sjogrens syndrome

Jimin Yoon, Min-Seok Lee, Ahsan Ausaf Ali, Ye Rim Oh, Yong Seok Choi, Sujin Kim, Namseok Lee, Se Gwang Jang, Seung‐Ki Kwok, Joon Young Hyon, Seunghee Cha, Yun Jong Lee, Sung Gap Im, Yoosik Kim

This study identifies mitochondrial double-stranded RNAs (mt-dsRNAs) as drivers of type I interferon responses and inflammatory phenotypes in Sjogrens syndrome.

bioRxiv · Sep 13, 2021 · PreprintMolecular Biology