Keonyong Lee

The paper investigates how intron lariats, especially those with transposable elements, trigger immune responses in cancer cells and shows that RNA editing and DBR1 depletion can be used to enhance anti-tumor effects.

This study identifies SLIRP as a key amplifier of antiviral signaling in autoimmune diseases through positive feedback regulation of mt-dsRNA.

The paper identifies alternative polyadenylation as a key mechanism by which inverted Alu repeats regulate gene expression and contribute to disease.

This study identifies mitochondrial dsRNAs as activators of PKR and TLR3, contributing to chondrocyte degeneration in osteoarthritis.