Sara Geraghty

Reprogramming of neuronal genome function and phenotype by astrocytes

This paper shows that astrocytes reprogram neuronal gene expression and chromatin accessibility, affecting thousands of genes and regulatory elements, including those linked to schizophrenia and Alzheimer's disease.

Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation

The paper identifies transcription factors for reprogramming human astrocytes to neurons using CRISPRa screens and scRNA-seq, showing INSM1's broad neurogenic activity and cofactor interactions.

Driver-associated transcriptional rewiring reveals conditional genetic vulnerabilities in cancer

Dyscovr identifies driver-associated transcriptional changes and prioritizes genes for therapeutic targeting in cancer.