Rapid CAR screening and circRNA-driven CAR-NK cells for persistent shed-resistant immunotherapy
Joo-Yoon Chung, Jisu Hong, Su‐Min Yee, Hye Won Lim, Dahye Lee, Sang-Won Yoon, Seung-Hwan Lee, Yu-Jin Jung, Seung Hun Shin, Song Cheol Kim, Chang‐Han Lee, Mihue Jang
This paper develops a method to create CAR-NK cells resistant to antigen shedding using circRNA and a novel scFv, showing comparable in vivo efficacy to lentiviral CAR-NK cells.
Signal Transduction and Targeted Therapy · Apr 10, 2026Peer-reviewedBioengineering