Mechanical Skin Stress-Induced Lesion Development via ATP-Amplified Neutrophil Extracellular Trap Formation
Daisuke Matsumoto, Katja Bieber, Ralf Joachim Ludwig, Daisuke Tsuruta, Sho Hiroyasu
This study identifies ATP released from keratinocytes as a mediator of mechanical stress-induced NETosis in neutrophilic skin diseases, showing that ATP enhances C5a-induced NET formation and exacerbates inflammation.
bioRxiv · Mar 14, 2026 · PreprintImmunology