Sho Hiroyasu

Extracellular Granzyme B Promotes Melanocytorrhagy, Melanocyte Senescence and Aberrant Epidermal Differentiation in Vitiligo and Is Therapeutically Targetable

This study shows extracellular Granzyme B contributes to vitiligo by causing melanocyte detachment, senescence, and abnormal epidermal differentiation, and identifies it as a therapeutic target.

Aberrant laminin signaling drives melanocyte dedifferentiation and unveils a tractable therapeutic target in vitiligo

This study identifies melanocyte dedifferentiation as a reversible mechanism in vitiligo and shows that targeting specific pathways can restore pigmentation.

Mechanical Skin Stress-Induced Lesion Development via ATP-Amplified Neutrophil Extracellular Trap Formation

This study identifies ATP released from keratinocytes as a mediator of mechanical stress-induced NETosis in neutrophilic skin diseases, showing that ATP enhances C5a-induced NET formation and exacerbates inflammation.

Inflammatory IL-1 signaling remodels epidermal stem cell compartments by suppressing Wnt activity

The paper shows that IL-1 signaling suppresses Wnt activity in epidermal stem cells during inflammation, leading to changes in stem cell compartments that can be reversed by Wnt reactivation.