Katja Bieber

The paper identifies BTK as a therapeutic target in antibody-mediated autoimmune diseases by mapping FcγR signaling in neutrophils using kinase inhibitors and disease models.

The paper tests a CD19xCD3 bispecific T cell engager in a mouse model of pemphigoid disease and finds it induces remission in 45% of treated mice.

This study identifies ATP released from keratinocytes as a mediator of mechanical stress-induced NETosis in neutrophilic skin diseases, showing that ATP enhances C5a-induced NET formation and exacerbates inflammation.

This study develops a human immune system mouse model for EBA, demonstrating that PDK1 inhibition reduces skin inflammation and immune cell activation.

This study shows ERK5 inhibition reduces neutrophil ROS release and ameliorates EBA, suggesting ERK5 as a therapeutic target in ROS-driven autoimmune diseases.

This study shows gut microbiota influences disease severity in an experimental pemphigoid model, with specific taxa linked to protection or inflammation.