Daisuke Tsuruta

This study shows extracellular Granzyme B contributes to vitiligo by causing melanocyte detachment, senescence, and abnormal epidermal differentiation, and identifies it as a therapeutic target.

This paper shows that staurosporine induces non-canonical melanocyte maturation by enhancing melanogenesis and dendritic remodeling, promoting pigmentation in vitro and in vivo.

This study shows that circadian clock genes BMAL1 and CLOCK regulate melanin synthesis in melanocytes by modulating vitamin D signaling.

This study identifies melanocyte dedifferentiation as a reversible mechanism in vitiligo and shows that targeting specific pathways can restore pigmentation.

This study identifies ATP released from keratinocytes as a mediator of mechanical stress-induced NETosis in neutrophilic skin diseases, showing that ATP enhances C5a-induced NET formation and exacerbates inflammation.

This study investigates RD-induced melanocyte loss in guinea pigs, finding basement membrane disorganization and MMP2 activity contribute to melanocyte detachment and depigmentation.