Mutating PINK1 gene by paired truncated sgRNA/Cas9-D10A in Cynomolgus Monkey
Zhenzhen Chen, Jian‐Ying Wang, Yu Kang, Qiaoyan Yang, Xueying Gu, Dalong Zhi, Yan Li, Bin Shen, Yuyu Niu
The paper describes the generation of PINK1 mutant cynomolgus monkeys using paired truncated sgRNA/Cas9-D10A to create a primate model of Parkinson's disease without affecting PINK1 protein expression.
bioRxiv · Oct 21, 2020 · PreprintGenetics