Author

Yuyu Niu

Kunming University of Science and TechnologyORCID 0000-0002-8797-4152Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Research Focus:gene regulatory network inference· 3 Organism:non-human primate· 3 Research Focus:differential expression· 2 Assay:scRNA-seq· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Weizhi JiiD· 2 shared Yu KangiD· 2 shared Alexander GoedeliD· 1 shared Ao CheniD· 1 shared Bin SheniD· 1 shared Bosiljka TasiciD· 1 shared Carl WardiD· 1 shared Chenyang Si· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersDevelopmental Biology

Weizhi JiORCID

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3 papers

Recent·Most cited

Amnion signals are essential for mesoderm formation in primates

Ran Yang, Alexander Goedel, Yu Kang, Chenyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, Peter J. Gruber, Yao Xiao, Chikai Zhou, Nevin Witman, Elif Eroğlu, Chuen-Yan Leung, Yongchang Chen, Jianping Fu, , Kenneth R. Chien

The paper identifies ISL1's critical role in primate mesoderm formation through a transcriptional atlas and CRISPR experiments in non-human primates.

Nature Communications · Aug 26, 2021Peer-reviewedDevelopmental Biology

Mutating PINK1 gene by paired truncated sgRNA/Cas9-D10A in Cynomolgus Monkey

Zhenzhen Chen, Jian‐Ying Wang, Yu Kang, Qiaoyan Yang, Xueying Gu, Dalong Zhi, Yan Li, Bin Shen, Yuyu Niu

The paper describes the generation of PINK1 mutant cynomolgus monkeys using paired truncated sgRNA/Cas9-D10A to create a primate model of Parkinson's disease without affecting PINK1 protein expression.

bioRxiv · Oct 21, 2020 · PreprintGenetics

Spatially resolved gene regulatory and disease vulnerability map of the adult Macaque cortex

Ying Lei, Mengnan Cheng, Zihao Li, Zhenkun Zhuang, Liang Li Wu, Yunong Sun, Lei Han, Zhi‐Hao Huang, Yuzhou Wang, Zifei Wang, Liqin Xu, Yue Yuan, Shang Liu, Taotao Pan, Jiarui Xie, , Xun Xu

The paper integrates single-cell ATAC and transcriptomic data with spatial transcriptomics to map regulatory features and disease vulnerabilities in macaque cortex.

bioRxiv · May 14, 2020 · PreprintNeuroscience