Yan Li

This study identifies ubiA gene mutations as the primary mechanism of ethambutol resistance in M. avium by analyzing clinical strains and resistant mutants.

This study shows Lamin A/C regulates DNA replication by controlling chromatin accessibility and PCNA recruitment, preventing excessive replication initiation and DNA damage.

The paper presents a multi-layered molecular dataset from iPSC-derived dopaminergic neurons to model Parkinson's disease genetic risk and provides a data browser for accessing these resources.

This study shows eIF4E is essential for the maternal-to-embryonic transition in mouse embryos, with knockout or inhibition causing developmental failure.

The paper describes the generation of PINK1 mutant cynomolgus monkeys using paired truncated sgRNA/Cas9-D10A to create a primate model of Parkinson's disease without affecting PINK1 protein expression.