GeneticsbioRxivPreprint
Mutating PINK1 gene by paired truncated sgRNA/Cas9-D10A in Cynomolgus Monkey
Zhenzhen Chen, Jian‐Ying Wang, Yu Kang…·Yuyu Niu
The paper describes the generation of PINK1 mutant cynomolgus monkeys using paired truncated sgRNA/Cas9-D10A to create a primate model of Parkinson's disease without affecting PINK1 protein expression.