Aging shapes infection profiles of influenza A virus and SARS-CoV-2 in human lung slices
Melanie Brügger, Carlos Machahua, Trix Zumkehr, Christiana Victoria Cismaru, Damian Jandrasits, Bettina Salome Trüeb, Sara Ezzat, Blandina I. Oliveira Esteves, Patrick Dorn, Thomas M. Marti, Gert Zimmer, Volker Thiel, Manuela Funke-Chambour, Marco P. Alves
This study shows that aged lung tissue reduces viral replication of IAV and SARS-CoV-2 but increases inflammatory responses, suggesting immune dysregulation contributes to severe disease.
Respiratory Research · Mar 24, 2025Peer-reviewedMicrobiology