Gert Zimmer

This study shows that a bovine-derived H5N1 virus replicates efficiently in human nasal epithelial cells at both 37°C and 33°C, with specific mutations enhancing replication at lower temperatures.

This paper re-engineers a cytolytic viral vector to be non-cytolytic, enhancing CD8 T cell immunity through reinforced type I IFN signaling.

This study evaluates an RNA replicon vaccine encoding HA and NA antigens of H1N1 virus in pigs, showing it prevents shedding of antigen-drifted H1N1 and H5N1 viruses.

This study shows that aged lung tissue reduces viral replication of IAV and SARS-CoV-2 but increases inflammatory responses, suggesting immune dysregulation contributes to severe disease.

This study investigates how temperature and pH affect the infectivity of H5N1 avian influenza viruses in dairy products, showing inactivation under certain processing conditions.

This paper develops an intramuscular prime/intranasal boost vaccination strategy against influenza A virus that achieves sterilizing immunity in pigs by combining a propagation-defective RNA vector with a modified live-attenuated vaccine.