Loss of host factor-mediated m6Am methylation of the viral RNA cap impairs SARS CoV-2 replication
Radha Raman Pandey, Nadine Ebert, David Homolka…·Ramesh S. Pillai
This study identifies PCIF1 as a host factor that methylates the SARS-CoV-2 RNA cap, enhancing viral replication and reducing disease severity in mice.