Volker Thiel

A bovine-derived influenza A virus (H5N1) shows efficient replication in well-differentiated human nasal epithelial cells at the temperature of the upper airways

This study shows that a bovine-derived H5N1 virus replicates efficiently in human nasal epithelial cells at both 37°C and 33°C, with specific mutations enhancing replication at lower temperatures.

Loss of host factor-mediated m6Am methylation of the viral RNA cap impairs SARS CoV-2 replication

This study identifies PCIF1 as a host factor that methylates the SARS-CoV-2 RNA cap, enhancing viral replication and reducing disease severity in mice.

Respiratory syncytial virus nonstructural protein 1 inhibits production of cytokines and chemokines by differentiated primary nasal epithelial cells cultured at air-liquid interface

This study shows RSV NS1 supports viral replication by inhibiting IFN production and chemokine secretion in nasal epithelial cells, using an ALI model for vaccine assessment.

Stress granules formed during different RNA virus infections show remarkable plasticity and substantial virus-specific differences in their formation and composition

This study compares stress granule formation and composition during MHV and SFV infections, revealing virus-specific differences in their proteomes, kinetics, and RNA content.

Aging shapes infection profiles of influenza A virus and SARS-CoV-2 in human lung slices

This study shows that aged lung tissue reduces viral replication of IAV and SARS-CoV-2 but increases inflammatory responses, suggesting immune dysregulation contributes to severe disease.

Deep learning-based 3D spatial transcriptomics with X-Pression

X-Pression reconstructs 3D expression signatures from volumetric microcomputed tomography data, demonstrating its utility in analyzing vaccine efficacy and viral replication in mouse lungs.

Neuroinvasion and anosmia are independent phenomena upon infection with SARS-CoV-2 and its variants

The paper investigates whether neuroinvasion and anosmia are independent outcomes of SARS-CoV-2 infection by analyzing clinical, olfactory, and neuroinflammatory responses in infected golden hamsters.

Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication

This study identifies critical residues in the nsp14 N7-MTase domain essential for betacoronavirus replication and suggests potential drug targets.

Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome

This study presents the cryo-EM structure of the mammalian ribosome during SARS-CoV-2 RNA translation, revealing the pseudoknot structure that facilitates ribosomal frameshifting and identifies a compound that inhibits viral replication.

Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV

Concurrent multi-omics of SARS-CoV-2 and SARS-CoV in A549 cells, integrated by network diffusion, maps shared and virus-specific host perturbations and nominates antiviral drug hotspots.

SARS-CoV-2 Nsp1 binds ribosomal mRNA channel to inhibit translation

This study shows SARS-CoV-2 Nsp1 binds to the 40S ribosomal subunit to inhibit translation by blocking mRNA entry, while viral mRNA enhances its own translation.