Biochemical, structural, and single-molecule characterization of LIG1 active site mutants demonstrate role of F635 and F872 residues for faithful ligation
Mustafa Kalaycioğlu, Mitchell Gulkis, Kar Men Lee, Surajit Chatterjee, Kanal Elamparithi Balu, Qun Tang, Jacob E. Ratcliffe, Erick Castro, Danah Almahdor, Melike Çağlayan
This study characterizes LIG1 active site mutants to show F635 and F872 residues are critical for accurate nick ligation and DNA repair.
bioRxiv · Nov 7, 2024 · PreprintBiochemistry