Author

Erick Castro

University of FloridaORCID 0000-0003-1161-4019Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

Kar Men LeeiD· 2 shared Melike ÇağlayaniD· 2 shared Camden Lerner· 1 shared Danah Almahdor· 1 shared Jacob E. Ratcliffe· 1 shared Jacob Ratcliffe· 1 shared Kanal Elamparithi Balu· 1 shared Mitchell GulkisiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

Kar Men LeeORCID

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2 papers

Recent·Most cited

BiochemistryJournal of Biological ChemistryPeer-reviewedApr 24, 2025

Mutagenic ligation of polβ mismatch insertion products during 8-oxoG bypass by LIG1 and LIG3α at the downstream steps of base excision repair pathway

Kar Men Lee, Erick Castro, Jacob Ratcliffe…·Melike Çağlayan

This study investigates how LIG1 and LIG3α handle nick sealing after polβ inserts dATP or dCTP during 8-oxoG bypass, showing ribonucleotide insertions disrupt repair coordination.

3 citations

experimental assaychromatin & epigenetic regulation

𝕏 PostBluesky

BiochemistrybioRxivPreprintNov 7, 2024

Biochemical, structural, and single-molecule characterization of LIG1 active site mutants demonstrate role of F635 and F872 residues for faithful ligation

Mustafa Kalaycioğlu, Mitchell Gulkis, Kar Men Lee…·Melike Çağlayan

This study characterizes LIG1 active site mutants to show F635 and F872 residues are critical for accurate nick ligation and DNA repair.

DOI 10.1101/2024.11.07.622578

humanexperimental assay

𝕏 PostBluesky