Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma
Bishal Tandukar, Delahny Deivendran, Limin Chen, Aravind K. Bandari, Noel Cruz‐Pacheco, Harsh Sharma, Meng Wang, Albert Xu, Daniel B. Chen, Christopher D. George, Annika L. Marty, Raymond Jaihyun Cho, Jeffrey B. Cheng, Drew K. Saylor, Pedram Gerami, , Alan Hunter Shain
This study uses multi-omic profiling to trace molecular changes in skin cells during carcinogenesis, identifying key mutations and spatial gene expression patterns in keratinocytes, actinic keratoses, and squamous cell carcinomas.
Nature Communications · Nov 27, 2025Peer-reviewedGenomics