Noel Cruz‐Pacheco

The paper identifies distinct melanocyte subpopulations in human skin based on mutation burden, showing LowMut cells are stem-like and spatially distinct from HighMut cells.

This study examines the molecular effects of indoor tanning by analyzing mutation patterns in melanocytes from tanning bed users and finds increased mutation burdens and distinct mutational signatures.

This study uses multi-omic profiling to trace molecular changes in skin cells during carcinogenesis, identifying key mutations and spatial gene expression patterns in keratinocytes, actinic keratoses, and squamous cell carcinomas.

This study shows that muscarinic agonists can restore non-healing salivary glands by reactivating endogenous regeneration and mitochondrial function through cholinergic-calcium signaling.

The paper develops software to infer copy number and detect single nucleotide variants in spatial transcriptomics data, applied to skin cancer to reveal genetic patterns and clonal populations.

This study shows that two distinct progenitor populations in salivary glands maintain ductal architecture after radiation damage through different mechanisms.