Albert Xu

This paper introduces a novel preprocessing method for MEG data using Fosters inverse with signal space separation to improve noise reduction and source localization.

This study uses multi-omic profiling to trace molecular changes in skin cells during carcinogenesis, identifying key mutations and spatial gene expression patterns in keratinocytes, actinic keratoses, and squamous cell carcinomas.

This study identifies a dependency on lysosomal exocytosis in FA pathway-deficient cells and tumors, revealing a new therapeutic target for FA-related cancers.

The paper identifies key residues in G3BPs that drive stress granule formation and gene expression changes under cellular stress, with G3BP2B showing specific roles in ER stress.

The paper quantifies RNA flow across subcellular compartments using TimeLapse-seq and identifies factors influencing mRNA life cycles.

This study shows IGHMBP2 deletion reduces global translation and activates the integrated stress response (ISR) in K562 cells, linking it to neuromuscular disease mechanisms.

The paper identifies GC content in coding sequences as a key factor in mRNA stabilization following DDX3X depletion, supported by analysis of RNA-seq data and ENCODE datasets.

The paper introduces Repair-seq to study DSB repair by profiling genetic perturbations and identifies dependencies and novel mechanisms in repair pathways.

This paper introduces a method to directly capture CRISPR guides in single-cell RNA-sequencing libraries, enhancing Perturb-seq scalability and enabling multi-omic measurements.

The paper explores genetic interaction manifolds using rich phenotypes from Perturb-seq to classify and mechanistically understand genetic interactions.