Bishal Tandukar

Somatic mutations distinguish melanocyte subpopulations in human skin

The paper identifies distinct melanocyte subpopulations in human skin based on mutation burden, showing LowMut cells are stem-like and spatially distinct from HighMut cells.

Molecular effects of indoor tanning

This study examines the molecular effects of indoor tanning by analyzing mutation patterns in melanocytes from tanning bed users and finds increased mutation burdens and distinct mutational signatures.

Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma

This study uses multi-omic profiling to trace molecular changes in skin cells during carcinogenesis, identifying key mutations and spatial gene expression patterns in keratinocytes, actinic keratoses, and squamous cell carcinomas.

Visualizing somatic alterations in spatial transcriptomics data of skin cancer

The paper develops software to infer copy number and detect single nucleotide variants in spatial transcriptomics data, applied to skin cancer to reveal genetic patterns and clonal populations.

Complementary In Vivo Approaches Reveal Quiescent Melanocytes in Anagen Outside the Hair Follicle Bulge

The paper identifies quiescent melanocytes outside the hair follicle bulge during anagen, showing they retain stem cell characteristics similar to quiescent McSCs in telogen.