The paper identifies distinct melanocyte subpopulations in human skin based on mutation burden, showing LowMut cells are stem-like and spatially distinct from HighMut cells.

Nature Cell Biology · Apr 27, 2026Peer-reviewedCell Biology

Molecular effects of indoor tanning

Pedram Gerami, Bishal Tandukar, Delahny Deivendran, Shantel Olivares, Limin Chen, Tuyet M. Tan, Tuyet Tan, Harsh Sharma, Aravind K. Bandari, Noel Cruz‐Pacheco, Darwin Chang, Annika L. Marty, Adam B. Olshen, Natália Faraj Murad, Jing Song, , Alan Hunter Shain

This study examines the molecular effects of indoor tanning by analyzing mutation patterns in melanocytes from tanning bed users and finds increased mutation burdens and distinct mutational signatures.

Science Advances · Dec 12, 2025Peer-reviewedGenomics

Genetic evolution of keratinocytes to cutaneous squamous cell carcinoma

Bishal Tandukar, Delahny Deivendran, Limin Chen, Aravind K. Bandari, Noel Cruz‐Pacheco, Harsh Sharma, Meng Wang, Albert Xu, Daniel B. Chen, Christopher D. George, Annika L. Marty, Raymond Jaihyun Cho, Jeffrey B. Cheng, Drew K. Saylor, Pedram Gerami, , Alan Hunter Shain

This study uses multi-omic profiling to trace molecular changes in skin cells during carcinogenesis, identifying key mutations and spatial gene expression patterns in keratinocytes, actinic keratoses, and squamous cell carcinomas.

Nature Communications · Nov 27, 2025Peer-reviewedGenomics

Visualizing somatic alterations in spatial transcriptomics data of skin cancer

Limin Chen, Darwin Chang, Bishal Tandukar, Delahny Deivendran, Joanna Poźniak, Noel Cruz‐Pacheco, Raymond Jaihyun Cho, Jeffrey B. Cheng, Iwei Yeh, Jean‐Christophe Marine, Boris C. Bastian, Andrew L. Ji, Alan Hunter Shain

The paper develops software to infer copy number and detect single nucleotide variants in spatial transcriptomics data, applied to skin cancer to reveal genetic patterns and clonal populations.

Genome biology · Nov 30, 2023Peer-reviewedGenomics