Impact of cellular prion protein expression on disease progression and pathology in two mouse models of Alzheimer's disease
Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Chun-Mun Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark A. Farrow, Andrew J. Nicoll, Dominic M. Walsh, John Collinge
This study investigates the impact of cellular prion protein expression on disease progression in two Alzheimer's disease mouse models, finding contradictory results that may be explained by differences in Aβ oligomer conformation.
bioRxiv · Sep 25, 2022 · PreprintNeuroscience