Author

Megan Powell

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Albert Tian CheniD· 1 shared Alexander SvanbergssoniD· 1 shared Allan MillsiD· 1 shared Andrew J. BarryiD· 1 shared Andrew J. NicolliD· 1 shared Benjamin E. DevermaniD· 1 shared C.-L. LiniD· 1 shared Casey KeyesiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Albert Tian ChenORCID

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2 papers

Recent·Most cited

An AAV capsid reprogrammed to bind human Transferrin Receptor mediates brain-wide gene delivery

Qin Huang, Ken Y. Chan, Jason Hongliu Wu, Nuria Roxana Botticello-Romero, Qingxia Zheng, Shan Lou, Casey Keyes, Alexander Svanbergsson, Jencilin Johnston, Allan Mills, C.-L. Lin, Pamela P. Brauer, Gabrielle Clouse, Simon Pacouret, John W. Harvey, , Benjamin E. Deverman

The paper develops a modified AAV capsid that targets the human Transferrin Receptor to enhance gene delivery to the CNS, showing improved reporter expression and therapeutic potential for Gaucher disease.

Science · May 16, 2024Peer-reviewedNeuroscience

Impact of cellular prion protein expression on disease progression and pathology in two mouse models of Alzheimer's disease

Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Chun-Mun Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark A. Farrow, Andrew J. Nicoll, Dominic M. Walsh, John Collinge

This study investigates the impact of cellular prion protein expression on disease progression in two Alzheimer's disease mouse models, finding contradictory results that may be explained by differences in Aβ oligomer conformation.

bioRxiv · Sep 25, 2022 · PreprintNeuroscience