Induction and characterisation of Abeta and tau pathology in AppNL-F/NL-F mice following inoculation with Alzheimer's disease brain homogenate
Silvia A. Purro, Michael Farmer, Emma Quarterman, Julia Ravey, David X. Thomas, Elizabeth Noble, Catherine Turnbull, Jacqueline M. Linehan, Tamsin Nazari, Sebastian Brandner, Mark A. Farrow, Dominic M. Walsh, John Collinge
This study inoculates AppNL-F/NL-F mice with AD brain homogenates to study A{beta} and tau pathology, finding prion-like propagation and new insights into their interactions.
bioRxiv · Jul 11, 2024 · PreprintNeuroscience