Author

Michael Farmer

MRC Prion Unit

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

John CollingeiD· 4 shared Jacqueline M. Linehan· 3 shared Sebastian BrandneriD· 3 shared Silvia A. Purro· 3 shared David X. ThomasiD· 2 shared Dominic M. WalshiD· 2 shared Elizabeth HilliD· 2 shared Elizabeth Noble· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersNeuroscience

John CollingeORCID

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4 papers

Recent·Most cited

Intracellular Trafficking SNARE Protein, Syntaxin-6, is a Modifier of Prion and Tau Pathogenesis in vivo and in Cellular Models

Elizabeth Hill, Mitali Patel, Juan Manuel Ribes, Jacqueline M. Linehan, Fuquan Zhang, Michael Farmer, Tatiana Jakubcova, Shyma Hamdan, Andrew Tomlinson, Tiziana Ercolani, Christian Schmidt, Parvin Ahmed, George Thirlway, Silvia A. Purro, Fabio Argentina, , Simon Mead

This study identifies syntaxin-6 as a modifier of prion and tau pathogenesis, showing it affects disease onset but not progression in experimental models.

bioRxiv · Feb 19, 2025 · PreprintNeuroscience

Induction and characterisation of Abeta and tau pathology in AppNL-F/NL-F mice following inoculation with Alzheimer's disease brain homogenate

Silvia A. Purro, Michael Farmer, Emma Quarterman, Julia Ravey, David X. Thomas, Elizabeth Noble, Catherine Turnbull, Jacqueline M. Linehan, Tamsin Nazari, Sebastian Brandner, Mark A. Farrow, Dominic M. Walsh, John Collinge

This study inoculates AppNL-F/NL-F mice with AD brain homogenates to study A{beta} and tau pathology, finding prion-like propagation and new insights into their interactions.

bioRxiv · Jul 11, 2024 · PreprintNeuroscience

Characterisation and prion transmission study in mice with genetic reduction of sporadic Creutzfeldt-Jakob Disease risk gene Stx6

Emma L. Jones, Elizabeth Hill, Jacqueline M. Linehan, Tamsin Nazari, Adam Caulder, Gemma F. Codner, Marie Hutchison, Matthew Mackenzie, Michael Farmer, Thomas Coysh, Michael Wiggins De Oliveira, Huda Al-Doujaily, Malin K. Sandberg, Emmanuelle A. Viré, Thomas J. Cunningham, , Simon Mead

This study investigates the role of Stx6 in prion disease by creating a mouse model with genetic depletion of Stx6 and finding a modest effect on prion disease incubation periods.

bioRxiv · Jan 10, 2023 · PreprintNeuroscience

Impact of cellular prion protein expression on disease progression and pathology in two mouse models of Alzheimer's disease

Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Chun-Mun Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark A. Farrow, Andrew J. Nicoll, Dominic M. Walsh, John Collinge

This study investigates the impact of cellular prion protein expression on disease progression in two Alzheimer's disease mouse models, finding contradictory results that may be explained by differences in Aβ oligomer conformation.

bioRxiv · Sep 25, 2022 · PreprintNeuroscience