Melissa A. Farrow

Multimodal Imaging of the Cellular and Extracellular Microenvironment on the Same Formalin-Fixed Paraffin-Embedded Tissue Section

The paper develops an optimized multimodal imaging workflow that preserves tissue integrity and enables comprehensive profiling of morphology, collagen, cell populations, N-glycans, and extracellular matrix peptides from a single tissue section.

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

The paper presents a multi-modal atlas of human kidney disease, identifying cellular and spatial mechanisms of injury resolution or failure and linking them to clinical outcomes.

Integrative Spatial Omics for Systems-Level Mapping of Pathological Niches

This paper introduces a multimodal pipeline for spatiomolecular analysis of tissue samples, demonstrating its application in Alzheimer's disease and type 2 diabetes.

Induction and characterisation of Abeta and tau pathology in AppNL-F/NL-F mice following inoculation with Alzheimer's disease brain homogenate

This study inoculates AppNL-F/NL-F mice with AD brain homogenates to study A{beta} and tau pathology, finding prion-like propagation and new insights into their interactions.

Inhibition of EGFR/ErbB does not protect against C. difficile toxin B

This study investigates whether inhibiting EGFR/ErbB receptors protects against C. difficile toxin B, finding no protective effect.

Impact of cellular prion protein expression on disease progression and pathology in two mouse models of Alzheimer's disease

This study investigates the impact of cellular prion protein expression on disease progression in two Alzheimer's disease mouse models, finding contradictory results that may be explained by differences in Aβ oligomer conformation.