Progranulin deficiency leads to reduced glucocerebrosidase activity
Xiaolai Zhou, Daniel H. Paushter, Mitchell D. Pagan, Dong-Sung Kim, Mariela Nunez Santos, Raquel L. Lieberman, Herman S. Overkleeft, Ying Sun, Marcus Bustamante Smolka, Fenghua Hu
This study shows that progranulin deficiency reduces glucocerebrosidase activity, linking it to lysosomal dysfunction in neurodegenerative diseases.
PLoS ONE · Jul 10, 2019Peer-reviewedNeuroscience